What is AOSD?
Adult-Onset Still's Disease (AOSD) is a rare autoinflammatory disease which can be caused by having too much of or being too sensitive to certain proteins, including IL-1β, and can lead to symptoms such as fever, rash, headache, feeling very tired (fatigue), or painful joints and muscles. AOSD is a type of Still's disease.
What causes AOSD?
AOSD is an idiopathic disease, which means that its cause is unknown. What is known about AOSD is that it's a rare autoinflammatory disease, meaning that it causes the body's immune system to attack healthy cells, leading to the signs and symptoms of AOSD.
How long will I have AOSD?
It can vary. You may need to undergo AOSD treatment for a period of several years or more. But with treatment, patients with AOSD can experience symptom improvement as time passes.
What is the difference between a localized and a systemic symptom?
As opposed to localized symptoms, such as pain in certain joints, systemic symptoms can affect the body as a whole. For example, a systemic symptom of AOSD is fever.
What will happen to me with AOSD?
What is ILARIS?
ILARIS® is a prescription medication that is FDA approved to treat Still's disease, including AOSD in adults. ILARIS works by attaching to and blocking interleukin-1 beta (IL-1β), a type of cytokine responsible for inflammation. For AOSD, ILARIS is given once a month as a subcutaneous injection right below the skin.
How can ILARIS help with active AOSD?
ILARIS can help relieve AOSD symptoms. FDA approval for AOSD was based on established efficacy of ILARIS in SJIA patients and evaluations of clinical data of AOSD and SJIA patients. In an SJIA study, ILARIS helped relieve SJIA symptoms including fevers (systemic) and painful and/or swollen joints (arthritic). In addition, some SJIA patients receiving ILARIS were able to reduce or stop taking corticosteroids altogether. For AOSD, ILARIS is given by a doctor or nurse as a once-monthly injection right below the skin. Talk to your doctor to find out if ILARIS may be a treatment option for you.
How fast does ILARIS work?
FDA approval for AOSD was based on established efficacy of ILARIS in SJIA patients and evaluations of clinical data of AOSD and SJIA patients. 190 children were entered into SJIA clinical studies to determine the impact of ILARIS on SJIA symptoms. Fifteen days after their first dose of ILARIS, approximately 8 out of 10 children taking ILARIS experienced improvement in active SJIA symptoms, such as fever and painful and/or swollen joints. None of the children taking ILARIS had fever by day 3 after the first dose.
Is ILARIS given intravenously?
ILARIS is not given as an intravenous infusion (infused inside a vein over a period of time). Instead, it is given as a subcutaneous (right under the skin) injection, or shot, by a doctor or nurse.
How often will I receive ILARIS?
For AOSD, ILARIS is given as a once-monthly injection. A home health nurse can be sent to your home to administer ILARIS. If you are eligible, this service and other ILARIS support options may be available for you.
Is support available to help me pay for ILARIS?
We're committed to helping you get access to ILARIS. Our ILARIS Companion representatives are here to help by working with your doctor, and:
Contacting your insurance company
Verifying insurance benefits and investigation of coverage
Addressing coverage issues
Navigating prior authorization and appeals, if needed
Providing co-pay* assistance for eligible patients with commercial insurance
Providing information about alternative assistance options for uninsured patients
*Limitations apply. Please contact ILARIS Companion at 866-972-8315 for more information.