About FMF About FMF

What is FMF?

Familial Mediterranean Fever (FMF) is a chronic, rare disease that's part of a group of diseases known as Periodic Fever Syndromes. FMF is an inherited condition, and typically develops in people younger than 20 years of age. While FMF can affect anyone, it primarily affects people of Turkish, Arabic, Armenian, or Jewish descent. Within these populations, it is estimated that FMF affects 1 out of every 200 people.

FMF is an autoinflammatory disease, meaning that it affects the body's immune system. This causes the immune system to work improperly, which can lead to FMF symptoms including fever, rash, stomach and chest pain, and joint inflammation.

What causes FMF?

FMF is caused by a mutation of the MEFV gene, which encodes a protein called pyrin. This leads to an overproduction of interleukin-1 beta (IL-1β), a protein that is part of the body's immune system. Too much IL-1β in the body can lead to inflammation and other symptoms of FMF.

If your child is diagnosed with FMF, ask your child's doctor about ILARIS®, the only once-monthly biologic medicine that is FDA approved to treat FMF.

Next: Signs and Symptoms