What is HIDS/MKD?

Hyperimmunoglobulin D Syndrome / Mevalonate Kinase Deficiency (HIDS/MKD) is a rare, chronic disease that's part of a group of diseases known as Periodic Fever Syndromes. HIDS/MKD is an inherited condition that usually develops in children who are less than 1 year old. While HIDS/MKD can affect anyone, it primarily occurs in people of Dutch or French descent. HIDS/MKD is very rare, with about 200 diagnosed cases worldwide.

HIDS/MKD is an autoinflammatory disease, meaning that it affects the body's immune system. This causes the immune system to work improperly, which can lead to HIDS/MKD symptoms including fever, rash, joint inflammation, swollen lymph nodes, and canker sores (aphthous ulcers).

What causes HIDS/MKD?

HIDS/MKD is a genetic disease that is caused by a mutation in the MVK (mevalonate kinase) gene, which can lead to inflammation and other HIDS/MKD symptoms.

If your child is diagnosed with HIDS/MKD, ask your child's doctor about ILARIS®, the only once-monthly biologic medicine that is FDA approved to treat HIDS/MKD.

Next: Signs and Symptoms