What are the Signs and
Symptoms of HIDS/MKD?

Hyperimmunoglobulin D Syndrome / Mevalonate Kinase Deficiency (HIDS/MKD) is marked by recurrent attacks, also known as flares. Flares can occur at any time, and usually last 3–7 days. Certain events are thought to trigger HIDS/MKD flares, including stress, vaccinations, or infections.

You can use the symptom tracker to keep track of all of your child's HIDS/MKD symptoms, which may include:



Abdominal and/or Stomach Pain

Abdominal and/or
Stomach Pain



Canker Sores

Canker Sores

Swollen Lymph Nodes

Swollen Lymph

Only a physician can diagnose HIDS/MKD, so be sure to talk to a doctor about all of the signs and symptoms that your child is experiencing.

As a caregiver, it may not be easy to recognize all of the symptoms of HIDS/MKD. But it's good to have an idea of what certain symptoms, like rash, can look like:

Patient with HIDS/MKD rash Patient with HIDS/MKD rash

Patient with typical HIDS/MKD rash.

Reproduced with permission from Cassidy JT, Petty RE, Laxer R, Lindsley CB, eds.
Textbook of Pediatric Rheumatology. 6th ed. Philadelphia PA: Saunders Elsevier; 2011

Children may fail to tell you about their pain, and some begin experiencing this pain so early in life that they actually think their pain is normal. It is important to notice when your child is hurting.

This can be a challenge, especially if your child cannot explain things very well yet. Check for crying, facial expressions, agitation, and level of ability to be consoled. You can also keep track of all of your child's signs and symptoms by using the symptom tracker.

Next: Managing HIDS/MKD